KV2.2 (KCNB2) Antibodies

Target Information

Kcnb2 (Kv2.2) encodes a Voltage-gated K+ channel which are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variation in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. The delayed rectifier-type (IK) channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites and are also found in a wide variety on non-neuronal cell types including pancreatic islet, alveolar cells and cardiac myocytes. Kv2.1 and Kcnb2 form distinct populations of K+ channels and these subunits are thought to be primarily responsible for IK in superior cervical ganglion cells. Functionally, Kcnb2 mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Diseases associated with KCNB2 include Brugada Syndrome.

Synonyms

9630047L19Rik; BB130875; CDRK; delayed rectifier potassium channel protein; kcnb2; kcnb2.L; kcnb2-a; kcnb2-b; Kv2.2; potassium channel Kv2.2; potassium channel, voltage gated Shab related subfamily B, member 2; potassium channel, voltage gated Shab related subfamily B, member 2 L homeolog; potassium channel, voltage gated Shab-related subfamily B, member 2; potassium voltage gated channel, Shab-related subfamily, member 2; potassium voltage-gated channel subfamily B member 2; potassium voltage-gated channel, Shab-related subfamily, member 2; voltage-gated potassium channel subunit Kv2.2